Basement Membrane in Diabetic Glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Accelerated glomerulosclerosis in alloxan-induced diabetic rabbits with anti-glomerular basement membrane nephritis.
To find how diabetes affects the processes of proliferative glomerulitis, we induced anti-glomerular basement membrane (GBM) nephritis by injection of anti-GBM antiserum in rabbits with alloxan diabetes (the DM-GN group) and in rabbits without the diabetes (the GN group), and compared the glomerular lesions between the two groups. Rabbits with alloxan diabetes only (the DM group) were also stud...
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I would like to show first the glomerulus of a 92-year-old man who did not have diabetes. It is perfectly normal. I want to emphasize that in the glomerulus there is not necessarily any ageing phenomenon per se. With the electron microscope there may be a slight increase in the thickness of the basement membrane of the glomerular capillary, but it is not visible by light microscopy. In the norm...
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Bleach, or hypochlorous acid (HOCl), is a very old chemical that is widely used as a decolorizing and disinfectant agent. The addition of a few drops of bleach to a cashmere sweater not only decolorizes the stain within 24 h at room temperature but also oxidizes the wool protein itself, such that the fine meshwork is replaced by a hole within a few days (Fig. 1, left panel). The chemistry behin...
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Basement membrane thickening is the most prominent and characteristic feature of early diabetic microangiopathy. Unknown is not only the causative process but also whether the thickening reflects increased synthesis of specific components. Because collagen type IV is uniquely present in basement membranes and represents their predominant structural element, we studied its expression in retinas ...
متن کاملBasement membrane.
Basement membrane has attracted less attention than the other components of connective tissue. But, like the other extracellular fibres and matrix materials, it can profoundly influence both the structure and function of advanced life forms. Usually taking the shape of thin, structureless cementing material between epithelial and connective tissue, basement membranes are widely distributed thro...
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ژورنال
عنوان ژورنال: Diabetes
سال: 1966
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.15.1.61